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If the activation stimuli are persistent in time and/or intense enough, the endothelium may become dysfunctional causing abnormal functional and structural changes, being the main consequence of the loss of vascular integrity with the detachment of ECs exposing a more thrombogenic extracellular matrix (ECM) ( Historically, our team initiated the research on endothelial activation and damage in the context of end-stage chronic kidney disease (CKD)
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Instead of being C-shaped, the central part of the meniscus is filled in with tissue
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