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The cancer cells were preincubated with NAC and subsequently treated with NP4 showed a reduced number of TNF-α secreted from the macrophages, suggesting that macrophage activation is associated with the NP4-induced oxidative stress
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In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses (Dong et al., 2022)
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