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The main obstacles include the complex design of nanocarriers, which hampers large-scale production, and the formation of a protein corona, a layer of proteins that adsorbs onto the surface of nanoparticles, effectively concealing the targeting molecules 3

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The assessment of the serum concentration of TPOAb and TgAb, which are serum biomarkers of HT, plays a fundamental role not only in the clarification of a diagnostic approach in the course of illness, but also in the prediction of progression regarding thyroid-followed immunity to hypothyroidism [19]