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Currently, the only applicable and most widely used therapeutic approach has been to improve BBB integrity by glucocorticosteroid (GC) treatment
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Oxycodone was able to efficiently evoke MOR internalization in HEK293 cells (Melief et al., 2010), but not in locus coeruleus neurons in Flag-MOR transgenic mice (Arttamangkul et al., 2008)
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