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Thus, ghrelin-induced GH expression in the amygdala may be involved in maladaptive changes following prolonged stress, such as posttraumatic stress disorder ( 33 , 34 )
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Evidence-based preventive strategies include propofol-based total intravenous anesthesia when appropriate, BIS-guided depth-of-anesthesia monitoring, and regional anesthetic techniques, all of which have been associated with a 25–40% reduction in POCD incidence
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