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Increased expression of iNOS and nNOS, excessive production of superoxide, mitochondrial membrane depolarization, the release of cytochrome c, and activation of caspase 3 leading to apoptosis of myenteric and submucosal neurons are prominent after oxaliplatin treatment (McQuade et al., 2016c)
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In a phase I Dose-Escalation study, CC-22 was evaluated in twenty-eight patients with advanced cancer
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