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Then, THF is metabolized to 5-methylTHF via the one-carbon metabolic pathway by methylenetetrahydrofolate reductase (MTHFR)
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Likewise, there are genetic alterations for which WES is not the appropriate technique, such as indels larger than 50 base pairs, tandem repeat expansions, structural rearrangements (inversions, translocations), or variants located in highly repetitive or low-coverage regions
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