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A negligible fraction of cells were propidium iodide + alone, indicating that X(PC) does not merely initiate unprogrammed necrotic cell death in SUP-B15 cells but rather directly activates a pyroptotic lytic death through caspase activation
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However, the silencing of BolA2 expression not only failed to induce a similar phenotype, but the co-silencing of Grx3 and BolA2 rescued the iron starvation phenotype to some degree (unpublished own data)
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