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Furthermore, they propose an upper threshold for zinc intake, at 25 mg/day for adults, and 7–10 mg/day for children aged between 4 and 13 years, to prevent potential zinc toxicity

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While the arachnoid barrier and the BCSFB have moderate permeability in the fetal, neonatal, and adult period, the BBB is the closest structure to the brain cells and hence, is considered the most important barrier (Benz and Liebner, Figure 1)