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Notably, the Nrf-2 signaling pathway is considered to be the dominant classical pathway in the antioxidant system that was activated to promote the expression of antioxidant enzymes, for instance, GSH-Px, SOD, and CAT, and thereby alleviated oxidative stress ( Nrf-2, GSH-Px , and HIF-1

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It can inhibit the massive replication of hepatitis B virus, improve the injury to liver cells triggered by the virus and the series of immune reactions, and protect the liver