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For example, it irreversibly binds toxic electrophiles in a reaction catalyzed by GST, depleting the cell of two GSH molecules in the process, but rendering the electrophiles inert so that they may be excreted from cells and tissues without causing further damage [54]
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From a morphological point of view, iron-intoxicated cells exhibit certain characteristics such as small mitochondria, condensed mitochondrial membrane density, reduced or absent mitochondrial cristae, and ruptured outer mitochondrial membranes (13, 26)
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