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Epidemiological studies indicate that chronic exposure to PQ can be a risk factor for neurological complications and neurodegenerative diseases such as seizures, coma, and Alzheimer’s, Parkinson’s, and Huntington’s disease (5, 10-14)
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82 The promising mechanism of action of TLK286 and its positive preclinical data have sparked a series of clinical trials where the prodrugs have been applied alone or in combination with other standard chemotherapeutic agents
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