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What the FDA’s Decision Means The FDA’s new policy will: Remove the “black box” warning for cardiovascular disease, breast cancer, and dementia on many MHT products

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When it becomes oxidized, it can break down yielding a large variety of compounds including a, β-unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carbon–carbon double bond or by Schiff base formation at the carbon–oxygen double bond (Esterbauer et al., 1991