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2.2.1 Morphological changes Morphologically, microglia have the ability to adopt different morphotypes depending on their state of activation, from quiescent (branched microglia) to hyperbranched, activated, amoeboid or rod microglia (de Hoz et al., 2013
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Adaptive response systems to variable O 2 tensions Low O 2 tension and HIFs The discovery of HIFs and their regulation by the von Hippel–Lindau tumor suppressor protein (pVHL) and PHDs represents a significant breakthrough in our understanding of cellular responses to hypoxia
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