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In addition to reducing protein disulfides, however, Trx1 and some Trx-family members, in particular the Trx-related protein of 14 kDa (TRP14), also participate in signaling by regulating protein- S- nitrosylation in NO-signaling and protein- S- persulfidation in H 2 S-signaling [114, 145, 149]
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Still, all these glutamatergic related factors account for a very small proportion of the overall heritability in schizophrenia and do not support a major role for genes known to impair NMDA-R function
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