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Radiation therapy, inflammatory bowel disease, administration of IV contrast, and toxic chemical exposure have rarely been implicated in cases of SJS and TEN [62]
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Readouts should reflect this compartment logic, combining peroxisome-targeted H 2 O 2 reporters (e.g., HyPer/roGFP-Orp1 with PTS1 “SKL” tagging) to track local oxidant dynamics with LC–MS lipid-peroxidation markers (F 2 -isoprostanes, oxidized phospholipids, HNE adducts) to quantify downstream burden and confirm that interventions reduce peroxide leakage while preserving necessary peroxisomal metabolism (Arnaud et al
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